News
NIAID Discovery Leads to Novel Probiotic for Eczema
Targeted Investigation of Microbiome 2 Treat Atopic Dermatitis (TIME-2)
Effects on the Skin Microbiome by a Moisturizer Formulated for Eczema-Prone and Sensitive Skin
Research
I was recently alerted about the research being done about skin pH and it’s contribution to eczema; theh TL;DR is that if you use a skin product with lower pH (eg Sebamed, SoteriSkin, Hypothesis):
J. Blaak, R. Wohlfart, and N. Y. Schürer, “Treatment of aged skin with a pH 4 skin care product normalizes increased skin surface pH and improves barrier function: results of a pilot study,” J. Cosmet. Dermatol. Sci. Appl., vol. 01, no. 03, pp. 50–58, 2011, doi: 10.4236/jcdsa.2011.13009.
A. Kilic et al., “Skin acidification with a water-in-oil emulsion (pH 4) restores disrupted epidermal barrier and improves structure of lipid lamellae in the elderly.” J. Dermatol., vol. 46, no. 6, pp. 457–465, 2019, doi: 10.1111/1346-8138.14891.
Angelova-Fischer I, Fischer TW, Abels C, Zillikens D. Accelerated barrier recovery and enhancement of the barrier integrity and properties by topical application of a pH 4 vs. a pH 5·8 water-in-oil emulsion in aged skin. Br J Dermatol. 2018 Aug;179(2):471-477. doi: 10.1111/bjd.16591. Epub 2018 May 28. PMID: 29577247.
J.-P. Hachem et al., “Acute acidification of stratum corneum membrane domains using polyhydroxyl acids improves lipid processing and inhibits degradation of corneodesmosomes.” J. Invest. Dermatol., vol. 130, no. 2, pp. 500–510, 2010, doi: 10.1038/jid.2009.249.
Andrew, P.V., Pinnock, A., Poyner, A. et al. Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis. Dermatol Ther (Heidelb) 14, 391–408 (2024). https://doi.org/10.1007/s13555-023-01084-x
Choi EH, Kang H. Importance of Stratum Corneum Acidification to Restore Skin Barrier Function in Eczematous Diseases. Ann Dermatol. 2024 Feb;36(1):1-8. https://doi.org/10.5021/ad.23.078
Acid-coated Textiles (pH 5.5–6.5) – a New Therapeutic Strategy for Atopic Eczema? Teresa Jaeger, Markus Rothmaier, Holger Zander, Johannes Ring, Jan Gutermuth, Mark D. Anliker. Acta Derm Venereol 2015; 95: 659–653